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Marijuana
Is Marijuana a Dangerous Drug?
Any discussion of marijuana should begin with the fact that there have been numerous official reports and studies, every one of which has concluded that marijuana poses no great risk to society and should not be criminalized. These include: the National Academy of Sciences' "Analysis of Marijuana Policy"(1982); the National Commission on Marihuana and Drug Abuse (the Shafer Report) (1973); the Canadian Government's Commission of Inquiry (Le Dain Report) (1970); the British Advisory Committee on Drug Dependency (Wooton Report) (1968); the La Guardia Report (1944); the Panama Canal Zone Military Investigations (1916-29); and Britain's monumental Indian Hemp Drugs Commission (1893-4).

It is sometimes claimed that there is "new evidence" showing marijuana is more harmful than was thought in the sixties. In fact, the most recent studies have tended to confirm marijuana's safety, refuting claims that it causes birth defects, brain damage, reduced testosterone, or increased drug abuse problems.
The current consensus is well stated in the 20th annual report of the California Research Advisory Panel (1990), which recommended that personal use and cultivation of marijuana be legalized: "An objective consideration of marijuana shows that it is responsible for less damage to society and the individual than are alcohol and cigarettes."

Is Marijuana Harmful?
Just as most experts agree that occasional or moderate use of marijuana is innocuous, they also agree that excessive use can be harmful. Research shows that the two major risks of excessive marijuana use are: respiratory disease due to smoking and accidental injuries due to impairment.

Marijuana and Smoking:
A recent survey by the Kaiser Permanente Center found that daily marijuana-only smokers have a 19% higher rate of respiratory complaints than non-smokers. These findings were not surprising, since it has long been known that, aside from its psychoactive ingredients, marijuana smoke contains virtually the same toxic gases and carcinogenic tars as tobacco. Human studies have found that marijuana smokers suffer similar kinds of respiratory damage as tobacco smokers, putting them at greater risk of bronchitis, sore throat, respiratory inflammation and infections.

Although there has not been enough epidemiological work to settle the matter definitively, it is widely suspected that marijuana smoking causes cancer. Studies have found apparently pre-cancerous cell changes in marijuana smokers. Some cancer specialists have reported a higher-than-expected incidence of throat, neck and tongue cancer in younger, marijuana-only smokers. Some cases have been fatal. While it has not been conclusively proven that marijuana smoking causes lung cancer, the evidence is highly suggestive. According to Dr. Donald Tashkin of UCLA, the leading expert on marijuana smoking:
"Although more information is certainly needed, sufficient data have already been accumulated concerning the health effects of marijuana to warrant counseling by physicians against the smoking of marijuana as an important hazard to health."
Fortunately, the hazards of marijuana smoking can be reduced by various strategies:
  1. Use of higher-potency cannabis, which can be smoked in smaller quantities
  2. Use of waterpipes and other smoke reduction technologies, and ingesting marijuana orally instead of smoking it


Is it True that One Joint Equals One Pack of Cigarettes?
Some critics exaggerate the dangers of marijuana smoking by fallaciously citing a study by Dr. Tashkin which found that daily marijuana smokers experienced a "mild but significant" increase in airflow resistance in the large airways greater than that seen in persons smoking 16 cigarettes per day. What they ignore is that the same study examined other, more important aspects of lung health, in which marijuana smokers did much better than tobacco smokers. Dr. Tashkin himself disavows the notion that one joint equals 16 cigarettes.

A more widely accepted estimate is that marijuana smokers consume four times as much carcinogenic tar as cigarettes smokers per weight smoked. This does not necessarily mean that one joint equals four cigarettes, since joints usually weigh less. In fact, the average joint has been estimated to contain 0.4 grams of marijuana, a bit less than one-half the weight of a cigarette, making one joint equal to two cigarettes (actually, joint sizes range from cigar-sized spliffs smoked by Rastas, to very fine sinsemilla joints weighing as little as 0.2 grams). It should be noted that there is no exact equivalency between tobacco and marijuana smoking, because they affect different parts of the respiratory tract differently: whereas tobacco tends to penetrate to the smaller, peripheral passageways of the lungs, marijuana tends to concentrate on the larger, central passageways. One consequence of this is that marijuana, unlike tobacco, does not appear to cause emphysema.

Does Prohibition Reduce the Harmfulness of Marijuana Smoking?
Whatever the risks of marijuana smoking, the current laws make matters worse in several respects:
  1. Paraphernalia laws have impeded the development and marketing of water pipes and other, more advanced technology that could significantly reduce the harmfulness of marijuana smoke.
  2. Prohibition encourages the sale of marijuana that has been contaminated or adulterated by insecticides, Paraquat, etc., or mixed with other drugs such as PCP, crack and heroin.
  3. By raising the price of marijuana, prohibition makes it uneconomical to consume marijuana orally, the best way to avoid smoke exposure altogether; this is because eating typically requires two or three times as much marijuana as smoking.


Has Anyone Ever Died from Using Marijuana?
The Kaiser study also found that daily marijuana users have a 30% higher risk of injuries, presumably from accidents. These figures are significant, though not as high as comparable risks for heavy drinkers or tobacco addicts. That marijuana can cause accidents is scarcely surprising, since marijuana has been shown to degrade short-term memory, concentration, judgment, and coordination at complex tasks including driving. There have been numerous reports of marijuana-related accidents - some of them fatal, belying the attractive myth that no one has ever died from marijuana. One survey of 1023 emergency room trauma patients in Baltimore found that fully 34.7% were under the influence of marijuana, more even than alcohol (33.5%); half of these (16.5%) used both marijuana and alcohol in combination. This is perhaps the most troublesome research ever reported about marijuana; as we shall see, other accident studies have generally found marijuana to be less dangerous than alcohol.

Nonetheless, it is important to be informed on all sides of the issue. Marijuana smokers should be aware that accidents are the number one hazard of moderate marijuana use. In addition, of course, the psychoactive effects of cannabis can have many other adverse effects on performance, school work, and productivity.

Is Marijuana a Major Road Safety Hazard?
A growing body of research indicates that marijuana is on balance less of a road hazard than alcohol. Various surveys have found that half or more of fatal drivers have alcohol in their blood, as opposed to 7 - 20% with THC, the major psychoactive component of marijuana (a condition usually indicative of having smoked within the past 2-4 hours). The same studies show that some 70% - 90% of those who are THC-positive also have alcohol in their blood. It therefore appears that marijuana by itself is a minor road safety hazard, though the combination of marijuana and alcohol is not. Some research has even suggested that low doses of marijuana may sometimes improve driving performance, though this is probably not true in most cases.

Two major new studies by the National Highway Transportation Safety Administration have confirmed marijuana's relative safety compared with alcohol. The first, the most comprehensive drug accident study to date, surveyed blood samples from 1882 drivers killed in car, truck and motorcycle accidents in seven states during 1990-91. Alcohol was found in 51.5% of specimens, as against 17.8% for all other drugs combined. Marijuana, the second most common drug, appeared in just 6.7%. Two-thirds of the marijuana-using drivers also had alcohol. The report concluded that alcohol was by far the "dominant" drug-related problem in accidents. It went on to analyze the responsibility of drivers for the accidents they were involved in. It found that drivers who used alcohol were especially culpable in fatal accidents, and even more so when they combined it with marijuana or other drugs. However, those who used marijuana alone appeared to be if anything less culpable than non-drug users (though the data were insufficient to be statistically conclusive). The report concluded, "There was no indication that marijuana by itself was a cause of fatal accidents." (It must be emphasized that this is not the case when marijuana is combined with alcohol or other drugs).

The second NHTSA study, "Marijuana and Actual Driving Performance," concluded that the adverse effects of cannabis on driving appear "relatively small" and are less than those of drunken driving. The study, conducted in the Netherlands, examined the performance of drivers in actual freeway and urban driving situations at various doses of marijuana. It found that marijuana produces a moderate, dose-related decrement in road tracking ability, but is "not profoundly impairing" and "in no way unusual compared to many medicinal drugs." It found that marijuana's effects at the higher doses preferred by smokers never exceed those of alcohol at blood concentrations of .08%, the minimum level for legal intoxication in stricter states such as California. The study found that unlike alcohol, which encourages risky driving, marijuana appears to produce greater caution, apparently because users are more aware of their state and able to compensate for it (similar results have been reported by other researchers as well) It should be noted that these results may not apply to non-driving related situations, where forgetfulness or inattention can be more important than speed (this might explain the discrepancy in the Baltimore hospital study, which looked at accidents of all kinds). The NHTSA study also warned that marijuana could also be quite dangerous in emergency situations that put high demands on driving skills.

Does Marijuana Prohibition Improve Public Safety?
There is no evidence that the prohibition of marijuana reduces the net social risk of accidents. On the contrary, recent studies suggest that marijuana may actually be beneficial in that it substitutes for alcohol and other, more dangerous drugs. Research by Karyn Model found that states with marijuana decriminalization had lower overall drug abuse rates than others; another study by Frank Chaloupka found decriminalization states have lower accident rates too. In Alaska, accident rates held constant or declined following the legalization of personal use of marijuana. In Holland, authorities believe that cannabis has contributed to an overall decline in opiate abuse. Recent U.S. government statistics show that the highest rates of cocaine abuse in the West were in Nevada and Arizona, the states with the toughest marijuana laws.

Does Drug Urinalysis Improves Workplace Safety?
There has never been a single, controlled scientific study showing drug urinalysis improves workplace safety. Claims that drug testing works are based on dubious anecdotal reports or the mere observation of a declining rate of drug positives in the working population, which has nothing to do with job performance. Such scientific studies as have been conducted have found little difference between the performance of drug-urine-positive workers and others.

The largest survey to date, covering 4,396 postal workers nationwide, found no difference in accident records between workers who tested positive on pre-employment drug screens and those who did not. The study did find that drug-positive workers had a 50% higher rate of absenteeism and dismissals; put another way, however, drug users had a 93.4% attendance record (versus 95.8% for non-users) and fully 85% kept their jobs for a year (versus 89.5% for non-users). An economic analysis of postal workers in Boston concluded that the net savings of drug testing were marginal, and that there could be many situations where it is not cost-effective. Another survey of health workers in Georgia found no difference in job performance between drug-positive and drug-negative workers.

Is Random Urinalysis Needed in Safety-Sensitive Transportation Jobs?
Government rules mandating random drug testing were promulgated without any prior statistical evidence that illicit drugs constituted an inordinate safety hazard. Not a single commercial passenger airline accident has ever been attributed to marijuana (or, for that matter, alcohol) abuse. Drug tests on rail workers found no elevated incidence of drug use among workers involved in accidents.

Random drug testing of transportation workers was enacted as a hysterical reaction to a single 1987 train collision, in which 16 Amtrak passengers were killed by a Conrail train that failed to stop. The engineer and brakeman of the Conrail train at fault were found to have recently smoked marijuana, though it was never firmly proven that marijuana caused the accident. The Conrail engineer had an extensive record of speeding and drunken driving offenses and was known by management to have drinking problems. Critical safety equipment that would have averted the accident was missing or disabled. A subsequent investigation by the National Transportation Safety Board recommended that Conrail improve both its management and equipment, but did not recommend random testing. Nonetheless, Congress responded by mandating random drug testing on the entire transportation industry, from airline flight attendants to gas pipeline workers.

Does a Single Joint's Effects Linger for Days and Weeks?
While it is true that THC and other cannabinoids are fat-soluble and linger in the body for prolonged periods, they do not normally affect behavior beyond a few hours except in chronic users. Most impairment studies have found that the adverse effects of acute marijuana use wear off in 2-6 hours, commonly faster than alcohol. The one notable exception was a pair of flight simulator studies by Leirer, Yesavage, and Morrow, which reported effects on flight simulator performance up to 24 hours later. The differences, described by Leirer as "very subtle" and "very marginal," were less than those due to pilot age. Another flight simulator study by the same group failed to find any effects beyond 4 hours. Similar "hangover" effects have been noted for alcohol.

Chronic users may experience more prolonged effects due to a build-up of cannabinoids in the tissues. Some heavy users have reported feeling effects weeks or even months after stopping. However, there is no evidence that these are detrimental to safety.

Is it True that Marijuana is 10 Times More Potent & Dangerous Now Than in the '60s?
The notion that marijuana has increased dramatically in potency is a DEA myth based on biased government data, as shown in a recent report by Dr. John Morgan. Samples of marijuana from the early '70s came from stale, low-potency Mexican "kilobricks" left in police lockers, whose potency had deteriorated to sub-smokable levels of less than 0.5%. These were compared to later samples of decent-quality domestic marijuana, making it appear that potency had skyrocketed. A careful examination of the government's data show that average marijuana potency increased modestly by a factor of two or so during the seventies, and has been more or less constant ever since.

In fact, there is nothing new about high-potency marijuana. During the sixties, it was available in premium varieties such as Acapulco Gold, Panama Red, etc., as well as in the form of hashish and hash oil, which were every bit as strong as today's sinsemilla, but were ignored in government potency statistics. While the average potency of domestic marijuana did increase with the development of sinsemilla in the seventies, the range of potencies available has remained virtually unchanged since the last century, when extremely potent tonics were sold over the counter in pharmacies. In Holland, high-powered hashish and sinsemilla are currently sold in coffee shops with no evident problems.

Contrary to popular myth, greater potency is not necessarily more dangerous, due to the fact that users tend to adjust (or "self-titrate") their dose according to potency. Thus, good quality sinsemilla is actually healthier for the lungs because it reduces the amount of smoke one needs to inhale to get high.

Is it True that Marijuana Kills Brain Cells?
Government experts now admit that marijuana doesn't kill brain cells. This myth came from a handful of animal experiments in which structural changes (not actual cell death, as is often alleged) were observed in brain cells of animals exposed to high doses of marijuana. Many critics still cite the notorious monkey studies of Dr. Robert G. Heath, which purported to find brain damage in three monkeys that had been heavily dosed with cannabis. This work was never replicated and has since been discredited by a pair of better controlled, much larger monkey studies, one by Dr. William Slikker of the National Center for Toxicological Research and the other by Charles Rebert and Gordon Pryor of SRI International. Neither found any evidence of physical alteration in the brains of monkeys exposed to daily doses of marijuana for up to a year. Human studies of heavy users in Jamaica and Costa Rica found no evidence of abnormalities in brain physiology. Even though there is no evidence that marijuana causes permanent brain damage, users should be aware that persistent deficits in short-term memory have been noted in chronic, heavy marijuana smokers after 6 to 12 weeks of abstinence. It is worth noting that other drugs, including alcohol, are known to cause brain damage.

Is it True that Marijuana Causes Sterility and Lowers Testosterone?
Government experts concede that marijuana has no permanent effect on the male or female reproductive systems. A few studies have suggested that heavy marijuana use may have a reversible, suppressive effect on male testicular function. A recent study by Dr. Robert Block has refuted earlier research suggesting that marijuana lowers testosterone or other sex hormones in men or women. In contrast, heavy alcohol drinking is known to lower testosterone levels and cause impotence. A couple of lab studies indicated that very heavy marijuana smoking might lower sperm counts. However, surveys of chronic smokers have turned up no indication of infertility or other abnormalities.

Less is known about the effects of cannabis on human females. Some animal studies suggest that marijuana might temporarily lower fertility or increase the risk of fetal loss, but this evidence is of dubious relevance to humans. One human study suggested that marijuana may mildly disrupt ovulation. It is possible that adolescents are peculiarly vulnerable to hormonal disruptions from marijuana. However, not a single case of impaired fertility has ever been observed in humans of either sex.

Is it True that Marijuana Causes Birth Defects?
While experts generally recommend against any drug use during pregnancy, marijuana has little evidence implicating it in fetal harm, unlike alcohol, cocaine or tobacco. Epidemiological studies have found no evident link between prenatal use of marijuana and birth defects in humans. A recent study by Dr. Susan Astley at the University of Washington refuted an earlier work suggesting that cannabis might cause fetal alcohol syndrome.

Although some research has found that prenatal cannabis use is associated with slightly reduced average birth weight and length, these studies have been open to methodological criticism. More recently, a well-controlled study found that cannabis use had a positive impact on birthweight during the third trimester of pregnancy with no adverse behavioral consequences. The same study found a slight reduction in birth length with marijuana use in the first two months of pregnancy. Another study of Jamaican women who had smoked marijuana throughout pregnancy found that their babies registered higher on developmental scores at the age of 30 days, while experiencing no significant effects on birthweight or length.

While cannabis use is not recommended in pregnancy, it may be of medical value to some women in treating morning sickness or easing childbirth.

Is it True that Marijuana Causes High Blood Pressure?
According to the NATIONAL ACADEMY OF SCIENCES, the effects of marijuana on blood pressure are complex, depending on dose, administration, and posture. Marijuana often produces a temporary, "moderate" increase in blood pressure immediately after ingestion; however, heavy chronic doses may slightly depress blood pressure instead. One common reaction is to cause decreased blood pressure while standing and increased blood pressure while lying down, causing people to faint if they stand up too quickly. There is no evidence that marijuana use causes persisting hypertension or heart disease; some users even claim that it helps them control hypertension by reducing stress.

One thing THC does do is to increase pulse rates for about an hour. This is not generally harmful, since exercise does the same thing, but it may cause problems to people with pre-existing heart disease. Chronic users may develop a tolerance to this and other cardiovascular reactions.

Is it True that Marijuana Damages the Immune System?
A variety of studies indicate that THC and other cannabinoids may exercise mild, reversible immuno-suppressive effects by inhibiting the activity of immune system cells know as lymphocytes (T- and B-cells) and macrophages. It is dubious whether these effects are of import to human health, since they are based mainly on theoretical laboratory and animal studies. According to a review by Dr. Leo Hollister:
"The evidence [on immune suppression] has been contradictory and is more supportive of some degree of immunosuppression only when one considers in vitro studies. These have been seriously flawed by the very high concentrations of drug used to produce immunosuppression. The closer that experimental studies have been to actual clinical situations, the less compelling has been the evidence."
The immune suppression issue was first raised in research by the notorious cannabophobe Dr. Gabriel Nahas, but a flurry of research by the Reagan administration failed to find anything alarming. The recent discovery of a cannabinoid receptor inside rat spleens, where immune cells reside, raises the likelihood that cannabinoids do exert some sort of influence on the immune system. It has even been suggested that these effects might be beneficial for patients with auto-immune diseases such as multiple sclerosis. Nevertheless, not a single case of marijuana-induced immune deficiency has ever been clinically or epidemiologically detected in humans.

One exception is the lungs, where chronic marijuana smokers have been shown to suffer damage to the immune cells known as alveolar macrophages and other defense mechanisms. It is unclear how much of this damage is due to THC, as opposed to all of the other toxins that occur in smoke , many of which can be filtered out by waterpipes and other devices.

There is no reason to think marijuana is dangerous to AIDS patients. On the contrary, many AIDS patients report that marijuana helps avert the deadly "wasting syndrome" by stimulating appetite and reducing nausea. Cannabinoids do not actually damage the T-cells, which are depleted in HIV patients: one study even found that marijuana exposure increased T-cell counts in subjects (not AIDS patients) whose T-cell counts had been low. Epidemiological studies have found no relation between use of marijuana or other drugs and development of AIDS.

Is it True that Marijuana Causes Chromosome and Cell Damage?
According to the NATIONAL ACADEMY OF SCIENCES, "Studies suggesting that marijuana probably does not break chromosomes are fairly conclusive." Cannabinoids in themselves are neither mutagenic nor carcinogenic, though the tars produced by marijuana combustion are. Some laboratory studies have suggested that high dosages of THC might interfere with cell replication and produce abnormal numbers of chromosomes; however, there is no evidence of such damage in realistic situations.

Is it True that Marijuana Leads to Harder Drugs?
There is no scientific evidence for the theory that marijuana is a "gateway" drug. The cannabis-using cultures in Asia, the Middle East, Africa and Latin America show no propensity for other drugs. The gateway theory took hold in the sixties, when marijuana became the leading new recreational drug. It was refuted by events in the eighties, when cocaine abuse exploded at the same time marijuana use declined.

As we have seen, there is evidence that cannabis may substitute for alcohol and other "hard" drugs. A recent survey by Dr. Patricia Morgan of the University of California at Berkeley found that a significant number of marijuana smokers and dealers switched to methamphetamine "ice" when Hawaii's marijuana eradication program created a shortage of marijuana. Dr. Morgan noted a similar phenomenon in California, where cocaine use soared in the wake of the CAMP helicopter eradication campaign.

The one way in which marijuana does lead to other drugs is through its illegality: persons who deal in marijuana are likely to deal in other illicit drugs as well.
(from NORML)
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